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Title: Math/Statistics/Education - Curve Fit Beginner's guide to nonlinear regression. Emphasizes how to interpret results.
The_Data_and_Story_Library Online library of datafiles and stories that illustrate the use of basic statistics methods. The goal is to provide data from a wide variety of topics so that statistics teachers can find interesting,

DISCUS Discovering Important Statistical Concepts Using Spreadsheets. Uses Excel spreadsheets to investigate statistical concepts.

Intro_Stat__EPR_Approach This site contains information about the Entity-Property-Relationship (EPR) approach to the introductory statistics course by Donald Macnaughton.

Introduction_to_Mathematical_Statistics Lecture notes from a year-long course in mathematical statistics.

Introductory_Statistics___Concepts,_Models,_and_Applications_by_David_Stockburger An online, searchable introductory statistics text. By David Stockburger of Southwest Missouri State University.

Intuitive_Biostatistics Harvey Motulsky, OUP (1995). Site for the book, with online extracts (PDF).


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curvefit.com. The complete guide to nonlinear regression. var TlxPgNm='index'; SPA curvefit.com was created by GraphPad Software, Inc. Send comments or questions to the author of these pages, Dr. Harvey Motulsky, president of GraphPad Software. In April 2003, GraphPad released Prism 4 and published Fitting Models to Biological Data using Linear and Nonlinear Regression. This book includes all the information that comprises curvefit.com, and much more. You can read this book as a pdf file. Introduction to regression Welcome to curvefit.com! The difference between linear and nonlinear regression Avoid Scatchard, Lineweaver-Burk and similar transforms Linear regression Fitting linear data with nonlinear regression Other kinds of regression Fitting a curve without choosing a model Nonlinear regression Introduction to nonlinear regression Choices to make when fitting data with nonlinear regression Why a computer program cannot pick a model for you Classic equations commonly used by biologists How models are derived Sum-of-squares as a measure of goodness-of-fit in nonlinear regression Weighting methods How nonlinear regression works Nonlinear regression with Prism Nonlinear regression with Prism Initial values with Prism Fixing parameters to constant values Method options with Prism Output options with Prism Default options for nonlinear regression Importing equations and the equation library User-defined equations Constraining variables in user-defined equations How to fit different portions of the data to different equations How to simulate a theoretical curve Interpreting the results of nonlinear regression Approach to interpreting nonlinear regression results Do the nonlinear regression results make sense? How certain are the best-fit values? How good is the fit? Does the curve systematically deviate from the data? Could the fit be a local minimum? Have you violated an assumption of nonlinear regression? Have you made a common error when using nonlinear regression? Comparing two curves Comparing the fits of two models Comparing fits to two sets of data (same equation) The distributions of best-fit values Why care about the distribution of best-fit values Using simulations to determine the distribution of a parameters Example simulation 1. Dose-response curves. Example simulation 2. Exponential decay. How to compare parameter distributions using Prism Radioligand binding Introduction to radioligand binding Law of mass action Ligand depletion What is nonspecific binding? Calculations with radioactivity Radioactivity calculator How the radioactivity calculator works Analyzing saturation radioligand binding data Introduction to saturation binding experiments Nonspecific binding in saturation binding Fitting specific binding data to determine Bmax and Kd Fitting  total binding data to determine Bmax and Kd Checklist for saturation binding Scatchard plots Analyzing saturation binding with ligand depletion Analyzing competitive binding data What is a competitive binding curve? Competitive binding data with one class of receptors Shallow competitive binding curves Competitive binding to two receptor types Homologous competitive binding curves Heterologous competitive binding with ligand depletion Analyzing kinetic binding data Dissociation ("off rate") experiments Association binding experiments Analysis checklist for kinetic binding experiments Using kinetic data to test the law of mass action Kinetics of competitive binding Analyzing dose-response curves Introducing dose-response curves Fitting sigmoid dose-response curves with Prism Why Prism fits the logEC50 rather than the EC50 Other measures of potency: pEC50, EC80, EC90, etc. Checklist. Interpreting a dose-response curve. The operational model of agonist action Dose-response curves in the presence of antagonists Analyzing enzyme kinetic data Introduction to enzyme kinetics How to determine Vmax and KM Comparison of enzyme kinetics with radioligand binding Displaying enzyme kinetic data on a Lineweaver- Burk plot Allosteric enzymes Enzyme kinetics in the presence of an inhibitor Reading unknowns from standard curves Introduction to standard curves How to fit standard curves Determining unknown concentrations from standard curves Standard curves with replicate unknown values Problems with standard curves GraphPad Prism Introducing GraphPad Prism Step #1. Enter data and create graph Step #2. Choosing nonlinear regression Step #3. Organized results Step #4. Statistical explanations Step #5. Summarize your experiment on one page Step #6. Analyze and graph a repeat experiment Download a free demo About GraphPad Software More information Download Analyzing Data with GraphPad Prism The GraphPad Guides Books about nonlinear regression Web sites on nonlinear regression, and related topics Nonlinear regression programs Contact the author Search curvefit.com                                                                                                                                                                                                                                                                                                             All contents copyright © 1999 by GraphPad Software, Inc. All rights reserved.
 

Beginner's

guide

to

nonlinear

regression.

Emphasizes

how

to

interpret

results.

http://www.curvefit.com/

Curve Fit 2008 December

dvd rental

dvd


Beginner's guide to nonlinear regression. Emphasizes how to interpret results.

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